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reported that sulforaphane exerted a neuroprotective effect in a 6-OHDA-induced acute mouse model and attributed it to the ability of sulforaphane to enhance glutathione levels and its dependent enzymes, to up-regulate Nrf2 and to modulate the ERK1/2 pathway in the brain 28
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Additionally, 1,25(OH)D promotes the expansion and functional enhancement of regulatory T cells (Tregs), not only by directly upregulating FoxP3 and the anti-inflammatory cytokine IL-10, but also by inducing a tolerogenic phenotype in dendritic cells, thereby indirectly facilitating Treg induction [168,169,170,171,172,173].Furthermore, 1,25(OH)D inhibits the mTORC1 pathway and activates fatty acid oxidation, creating a favorable metabolic milieu for Treg differentiationa combined epigeneticmetabolic regulatory mechanism that is emerging as a central feature of Vitamin Dmediated immunomodulation [174, 175]
Three different mechanisms may be involved in this hypothesis
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