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The STEP program included four phase 3 clinical trials with over 4,500 participants

Overall, 1 year after initiating semaglutide OW, there was a mean 4.4 kg weight reduction and a decrease in HbA1c of 1.5% in the all semaglutide OW cohort

Recovery varies by procedure type

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The authors also described that germ-free mice and mice orally administered antibiotics showed lower cecal SCFA concentrations and IGF-1 production, resulting in decreased bone growth (77)