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NTHi counteracts this response by producing an IgA1 protease, an extracellular endopeptidase which specifically cleaves IgA1 (Rao et al., 1999)

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Our meta-analysis of 49 murine single-cell datasets revealed that Mtnr1a transcripts were detectable in the lung, whereas Mtnr1b was largely absent ( Supplementary Figure 3A ), whereas in a similar analysis of over 250 human datasets, both Mtnr1a and Mtnr1b were detected ( Supplementary Figure 3B )