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Discontinuation and weight regain How often people stop the medication TRIUMPH-4 (n=445, 68 weeks, obesity with knee osteoarthritis): 18.2% on 12 mg, 12.2% on 9 mg, 4% on placebo 2 TRANSCEND-T2D-1 (n=537, 40 weeks, type 2 diabetes): 5.1% on 12 mg, 4.5% on 9 mg, 0% on placebo 3 Phase 2 (n=338, 48 weeks): 6 to 16% across doses, 1% on placebo 1 For comparison, Wegovys STEP-1 trial reported a discontinuation rate of around 7% due to side effects, and Mounjaros SURMOUNT-1 reported a similar rate

The fiber and prebiotic components produce real improvements in appetite and digestion

doi:10.1038/s41467-023-41065-4

Pop OL, Suharoschi R, Gabbianelli R (2022) Biodetoxification and protective properties of probiotics

To help regulate blood sugar and insulin levels

Side Effects: What Patients Should Watch For Semaglutide, tirzepatide, and investigational medications such as retatrutide can all involve side effects, especially gastrointestinal effects