The peptide's ability to cross the blood-brain barrier and its stability may make this route viable
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We hypothesised that the reported brainstem transcriptomic changes might reflect modulation of NTS Ppg neuron activity downstream of GIPR antagonism in the hypothalamus and therefore tested the effect of GIPR-antag on mice with ablated NTS Ppg neurons (Ppg NTS-Abl ) generated by bilateral stereotactic injection of AAV-DTA into the NTS of Ppg-Cre or control mice (Cre-negative mice receiving AAV-DTA into the NTS) (Fig
Consistent with the results of GGCT knockdown in vitro, depletion of GGCT significantly reduced tumor volume and weight compared with control groups
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Natural killer cells Aging significantly affects the number, function, and phenotype of NK cells, which are critical components of the innate immune system