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At higher doses, some concern exists about pro-inflammatory effects: LL-37 can activate NF-kB pathways, potentially worsening certain inflammatory conditions

Raun K, Hansen BS, Johansen NL, Thgersen H, Madsen K, Ankersen M, Andersen PH

HepG2 cell culture, treatment and cellular fractionation HepG2 cells were grown in poly-L-lysine coated 75 cm 2 flasks (2.02.510 6 cells/ml) in DMEM medium supplemented with 1% nonessential amino acids, 2 mM glutamine, 10% heat inactivated fetal bovine serum in the presence of 5% CO295% air at 37C as described before [23]

Imperial Peptides UK supplies GHK-Cu 50mg strictly for research use only, supported by clear product information, traceability and batch-focused documentation.

One important caution: very high doses of green tea extract in supplement form have paradoxically been associated with liver stress in rare cases