The existence of the remnant receptor pathway was suggested by the fact that patients with homozygous FH, who completely lack LDLR function, have severely elevated levels of LDL-C but normal blood levels of triglycerides
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In prostate cancer cells androgens have been shown to upregulate the expression of IGF-1R and as a consequence results in increased proliferation and invasion when stimulated with IGF-1 (Pandini et al., 2005)
