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While a high-fat diet increases cholesterol secretion into the bile, which can lead to sludge and stone formation, 9 rapid weight loss and less frequent, low-fat meals also contribute to sludge and stone formation, as discussed later
Under continuous stimulation of IGF-1, IGF-1R/MAPK/PI3K signaling is activated, leading to resistance to estrogen tamoxifen and fluvestrant
eBioMedicine 99 , 104931 (2023)
Although rare, gallbladder cancer can be considered as a highly fatal complication of gallstones, since the tumour has a high grade of malignancy and diagnosis is often delayed, despite that it is an incidentaloma in 12% of cases during cholecystectomy [170, 171]
