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Telomeres, the protective caps at the end of chromosomes, naturally shorten with age, leading to cellular aging and reduced function

Studies indicate that EP300 knockout in human colorectal cancer HCT116 cells and HEK293T cells reduces global lactylation and H3K18la modification levels [8]

Reduced glutathione has also been reported to be lower in the plasma of children with autism spectrum disorders [87, 91]