Generalizing to spinal cord and brain tissues, immunohistochemical analysis showed that infiltrating inflammatory cells were largely restricted to the central nervous system
The environmental estrogen, nonylphenol, activates the constitutive androstane receptor
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However, with the more recently introduced SGLT2 inhibitors and GLP-1 receptor agonists having shown impressive cardiovascular risk reduction in addition to glycemic control efficacy, these newer agents may also be considered as first-line therapies in patients with pre-existing cardiovascular or renal disease (Garber 2020)
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