Peake JM, Suzuki K, Hordern M, Wilson G, Nosaka K, Coombes JS
Traditional laser treatments, for example, can generate excessive heat that damages surrounding tissues, potentially leading to post-inflammatory hyperpigmentation that worsens the condition rather than improving it
In some embodiments, the otoprotectant is a compound of Formula (VIII) having the structure of Formula (VIIIa): In some embodiments, the otoprotectant is a compound of Formula (IX): wherein: R 1 is C 6 -C 10 aryl or C 3 -C 9 heteroaryl, wherein C 6 -C 10 aryl and C 3 -C 9 heteroaryl are optionally substituted with one or more R 4
Patients should maintain adequate fluid intake based on individual needs, with the goal of maintaining pale yellow urine color
These osteoclast defects appear to be cell-autonomous, as they could be recapitulated by culturing osteoclast precursors from the global IGF-I KO mice, which showed reduced ability to differentiate into mature osteoclasts (65)
J.BourbeauJ.CelliB