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The four-week minimum exists because shorter intervals typically lead to worse side effects without improving long-term outcomes

Para el anlisis, el sobrepeso y la obesidad se definieron segn las definiciones de IMC, as como los cdigos de diagnstico, y los criterios de inclusin exigan que esto se registrara al menos un ao antes de su fecha de ndice

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The most common problems were gastrointestinal, mainly nausea, and they showed up most often while the dose was being raised

Certain thyroid conditions and predispositions require careful evaluation before initiating semaglutide or tirzepatide therapy