Examples where extra caution is commonly advised (based on GLP-1 class evidence and expert reviews): Oral contraceptive pills (birth control pills) concern that effectiveness may be reduced around initiation/dose escalation due to delayed absorption (this has been noted with similar drugs and discussed for retatrutide as a potential issue)
JAMA Network Open, 6(5), e2314493
Dosage calculations for prefilled semaglutide syringes Getting the math right before you start drawing is critical
Acta Pharmaceutica Sinica B , vol
Lustig RH, Greenway F, Velasquez-Mieyer PA, Heimberger D, Schumacher D, Smith D, Smith W, Soler N, Warsi G, Berg W, Maloney J, Benedetto J, Zhu W, Hohneker J: A multicenter, randomized, double-blind, placebo-controlled, dose-finding trial of a long acting formulation of octreotide in promoting weight loss in obese adults with insulin hypersecretion
While complete adverse event data from most TRIUMPH trials is still pending full publication, early reported data aligns with Phase 2 observations