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36,38,39 Compared to oral administration, whereby under 10% actually enters the blood stream, 52 orobuccal administration leads to over 80% absorption directly into the systemic circulation

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JAMA 307 , 19341940 (2012)

However, autophagosome markers are decreased which may indicate there was a defect in the removal of mitochondria fragments, while reduced mitophagy markers may indicate that there were less healthy mitochondria fragments to be recycled

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