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These results represent the greatest mean body-weight reduction reported to date for any incretin-based investigational therapy in a clinical trial of this duration.6 Although the triple-agonist mechanism offers substantial promise, glucagon receptor activation introduces theoretical safety concerns, including transient hyperglycemia, increased heart rate and potential hepatic effects

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Miracco C, Margherita De Santi M, Schurfeld K, Santopietro R, Lalinga AV, Fimiani M et al

a , RNA-seq analysis of Mp FER and Mp LLG in vegetative and sexually-reproductive tissues from male and female wild type Marchantia ( b , GUS staining showing the global expression of Mp FER in antheridiophores (left), antheridia (top right) and thalli (bottom right)

Aperghis M, Johnson IP, Cannon J, Yang SY, Goldspink G