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New oral GLP-1 drug helps maintain weight loss achieved with injectable drugs Patients who used the oral GLP-1 agonist orforglipron after losing weight with a subcutaneous GLP-1 medication were able to keep most of the weight off, a trial has found

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Results Cystine deprivation leads to rapid death of TNBC cells by mitochondrial oxidative stress independent of GSH loss To investigate the dependence of BC cells on Cyss, we first examined the cytoplasmic Cys/Cyss content in TNBC (Hs 578T and MDA-MB-231) and non-TNBC cell lines (MCF7), cultured for 8 h in the absence of Cyss or in the presence of buthionine sulfoximine (BSO), an inhibitor of GCL (Fig