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First, ionizing radiation induces DNA double-strand breaks in vascular endothelial cells, activating the DNA damage response (DDR) machinery and p53-dependent checkpoint signaling, ultimately leading to arrest of the endothelial cell cycle and functional impairment 38,39

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Extending treatment duration from 3 to 9 years resulted in ICERs ranging from 14,020 to 15,487 per QALY

Comparing Weight Loss Results The head-to-head SURMOUNT-5 study shows that the dual-hormone treatment approach helped in reducing 20% of body weight compared to the single-hormone treatment that led to 15% weight loss

Beyond their effects on insulin secretion, accumulating evidence demonstrates that GLP-1 RAs also enhance insulin sensitivity and reduce systemic insulin resistance

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