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[6] Because IGF-1 LR3 retains strong IGF-1R affinity, it initiates the same receptor activation cascade the difference lies in bioavailability, not in the fundamental signaling logic

Experimental design Figure 1 shows the experimental design

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Inhibition of LDHA decreases the inflammatory response induced by bTNF- in bFLS As previously demonstrated, bTNF- increases the expression of LDHA, an enzyme that converts pyruvate to lactate with the production of NAD +