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Heres how GLP-1 works: Stimulates insulin secretion to aid blood glucose levels Reduces glucagon (a hormone that raises blood sugar) Slows gastric emptying, helping you feel full longer Suppresses appetite, leading to lower food intake GLP-1 also influences the brains appetite centers and improves communication between the gut and the brain

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Mol Cell Biochem 220:117125 Brown LJ LM, Hasan NM, Kendrick MA, Stoker SW, MacDonald MJ (2009) Chronic reduction of the cytosolic or NAD(P)-mitochondrial malic enzymes does not affect insulin secretion in a rat insulinoma cell line

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