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Like 5-aza-2-deoxycytidine, a known DNMT inhibitor, curcumin downregulates DNMT proteins

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When SAM-e loses a methyl group, it becomes SAH (s-adenosyl-homocysteine), which then is hydrolyzed to form homocysteine.[ref] This is called the methylation cycle or the methionine cycle

Proper nutrition means eating a colorful diet (lots of fruit and vegetables) alongside rich sources of protein and whole grains, while minimizing heavily processed foods