Common cardiometabolic risk factors include: Excess visceral or abdominal fat High blood pressure High triglycerides Low HDL cholesterol Elevated LDL cholesterol or ApoB when measured Prediabetes or type 2 diabetes Insulin resistance Fatty liver disease or MASH risk Sleep apnea Chronic inflammation Low muscle mass or poor fitness Smoking or nicotine exposure Family history of premature cardiovascular disease These issues often reinforce one another
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Exchange factor directly activated by cAMP (Epac) upregulates expression of the negative leptin signaling modulators SOCS3 and PTP1B, whereas inhibits the positive modulators STAT3 and S6K1, impairing the leptin signaling cascades in hypothalamic neurons [213, 214]
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Sands BE, Podolsky DK: The trefoil peptide family
