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The medication does not become less potent

Clinically, this potent effect is demonstrated by agents like semaglutide, which, in phase 2 trials, achieved MASH resolution without worsening fibrosis in a significant percentage of patients (Newsome et al., 2021

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EX-4 affects the microglia (immune cells in the brain) through an autocrine mechanism, in which interleukin-10 (IL-10) mediates -endorphin expression