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Typical weekly range: 28 mg once weekly (gradual escalation over 812 weeks)

203210, pubmed.ncbi.nlm.nih.gov/23892832/

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Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes

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In PD patients, misfolded -synuclein is released from injured neurons into the extracellular fluid, where it binds to Toll-like receptors (TLRs), Fc receptors (FcR), or nucleotide-binding oligomerization domain-like receptors (NLRPs), further activating microglia (181184)