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THC targets TRP channels (mainly TRPV2), the nuclear receptor PPAR that regulates adipocyte differentiation and metabolism, the G-proteincoupled receptors GPR18, a GPCR involved in immune cell signaling, GPR55, a GPCR that regulates calcium signaling and neuronal activity, and glycine receptors, which mediate inhibitory neurotransmission in the central nervous system

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