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Despite these promising results, MK-0493 did not show clinically significant efficacy in obese human participants at either a 400 mg PO dose or a step-titrated 800 mg PO dose ( ad libitum energy intake model, MK-0493 was associated with a small and marginally significant reduction in total 24-hour energy intake, whereas 30 mg of sibutramine (positive control) was associated with a significant reduction in total 24-hour energy intake ( While MK-0493 did not achieve clinical success, an analysis of these studies can provide potential rationale for failure

donde se realiza la betaoxidacin, siendo esta la principal fuente de energa para el msculo cardiaco y esqueltico

More than 95% of the body's stores are found in skeletal muscle

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