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Ageing Res Rev 83:101790

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In vitro studies have shown that addition of DPP-4 is associated with impaired insulin signaling in primary human adipocytes, skeletal muscle, and smooth muscle cells (79), while conversely, silencing Dpp4 (using short interfering RNA) resulted in improved adipocyte insulin responsiveness (89)

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However, in type 2 diabetes, they have been associated with only modest benefits [15]

However, there are Wegovy patients in Houston who have experienced severe GI problems even though they followed all of their doctor's instructions to the letter