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REM tends to show up more in the second half

The Official Guidelines instruct that cachexia requires documentation of a causative underlying chronic illness

No serious cardiovascular events have been attributed to retatrutide in published trials

GLP-1 medications such as semaglutide work primarily by suppressing appetite

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Factors contributing to the suboptimal performance of drugs include the selection of drug targets, the use of biomarkers and animal models in experimental designs, and other issues such as late treatment initiation, dose-dependent side effects, challenges in BBB permeability, and the heterogeneous presentation of patients