Radiofrequency microneedle was reported as an effective treatment for refractory melasma, although no large randomized controlled studies have been performed [115,116,117]
Tepmongkol et al., 2008) was reported in a phase II clinical trial that on the other hand concluded a not complete response of patients (Kebebew et al., 2009)
They provide relief right where its needed, with much less absorption into the bloodstream
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