270,271 Additionally, slower gastric emptying helps stabilize postprandial blood glucose levels
PubMed Del Prato, S., Kahn, S.E., Pavo, I., Weerakkody, G.J., Yang, Z., Doupis, J., Aizenberg, D., Wynne, A.G., Riesmeyer, J.S., Heine, R.J., Wiese, R.J., & SURPASS-4 Investigators
Insulin resistance plays an important role in the pathophysiology of comorbid T2DM and depression and can be a trigger for dysregulation of insulin- and GLP-1-mediated signaling (both central and peripheral), neuroendocrine disorders (hypothalamicpituitaryadrenal system dysfunction and monoaminergic neurotransmission disorders), chronic low-intensity inflammation, oxidative stress, and disorders of the microbiota-gut-brain system, reducing the level of neurotrophic factors in the brain and changing synaptic plasticity
Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes
This supports the value of GLP-1 receptor agonists in personalized healthcare strategies
11 , e70076 (2025)
