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Via direct targeting of TREM2 (triggering receptor expressed on myeloid cells 2), Hecubine alleviated neuroinflammation and oxidative stress in both in vivo (4 dpf zebrafish larvae) and in vitro (BV-2 microglial cells) models, by modulating the Nrf2 and TLR4 signaling pathways (Figure 3C) (Li et al., 2024)

As we age, or when we face high stress and environmental pollutants, our natural levels of this master antioxidant tend to drop

Deposition of protein material within hepatocyte cytoplasm

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no congestion within hepatic veins with parenchymal liver phase, mild congestion in pulmonar artery with parenchymal lung phase, normal heart filling with contrast media (venography through inferior caval vein))

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