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Biochemically, however, impaired methylation can arise through at least two major routes: the body may not produce enough, its principal methyl donor, or it may accumulate too much, a feedback inhibitor that slows many methyltransferase reactions

(2011) 300:R81826

Further research will have to be carried out to explain this dilemma

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Beyond direct antioxidant work, glutathione plays a core part in toxin clearance

The region containing the greatest amount of variability between the assorted classes is that of helix 2, where one of three different amino acid residues interacts with the glycine residue of glutathione