They have discovered that polyphenols may exhibit the ability to scavenge free radicals through (1) direct reaction with reactive oxygen species (ROS), (2) enhanced dismutation of free radicals to compounds with much lower reactivity, (3) inhibition of catalase enzyme activity, (4) increased activity of antioxidant enzymes such as SOD, (5) chelation with pro-oxidative metals like iron and copper, and (6) increasing the effectiveness of other small antioxidants like tocopherols and ascorbic acid [208, 209]
: ,
Additionally, the absence of molecular pathway analysis limits mechanistic interpretation of the observed protective effects
Clinical Evidence on Long-Term Glutathione Depletion and Health Outcomes Several in vitro and animal studies demonstrate acetaminophen-induced glutathione depletion impairs antioxidant defense and cellular repair
This reaction diminishes the concentration of DPPH radicals, a change that can be quantified spectrophotometrically
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