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When multiple species of pregnant animals received topiramate at clinically relevant doses, structural malformations, including craniofacial defects, and reduced fetal weights occurred in offspring

doi: 10.1038/s41392-022-01149-x 38

For genetically predicted acetyl-carnitine, we also found an association with higher triglycerides (0.06, 95% CI 0.04 to 0.07) and lower HDL-cholesterol ( 0.03, 95% CI 0.05 to 0.02) (Additional file 2: Fig

Antibiotic mixture administered in NOD/ShiLt mice pre-EAE improved the disease course, correlated with enhanced Tregs and altered gut microbiota in Peyer's patches (Colpitts et al., 2017)

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During this trial, patients lost up to 21% of their weight