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The antioxidant activity persists for several hours after application, providing ongoing defense during peak exposure periods
GSH replenishment in human tissues is difficult due to its shorter half-life, and not easy to penetrate the plasma membrane hence use of prodrugs/precursors such as cysteine, and glycine is the most promising approach 4,45
Treatment with NAC was able to attenuate the diminished ratio GSH/GSSG in animals [93], and the repletion of glutathione pool by NAC counteracted allergen induced airway reactivity/inflammation and restored oxidant-antioxidant balance [94]

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