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Woolston CM, Al-Attar A, Storr SJ, Ellis IO, Morgan DA, Martin SG

The molecular mechanism by which the PfK13 mutations confer artemisinin resistance in clinical isolates may involve multiple cellular and metabolic processes, including hemoglobin uptake and digestion, the unfolded protein stress response, mitochondrial functions, oxidative stress responses (including tRNA thiouridine modification reprogramming), and an enhanced DNA damage repair mechanism 3, 811, 1320

Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial

It has also a great supportive action on the immune system

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Prediction of nonalcoholic fatty liver disease via a novel panel of serum adipokines