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The SURMOUNT-1 trial showed tirzepatide at its highest dose produced 22.5% weight loss over 72 weeks

Therefore, clinicians are asked to consider these therapies for PDAC risk reduction, provided there are no contraindications

This option is particularly relevant for patients on stable maintenance doses who want to save money on brand-name medications rather than using unsafe compounded alternatives

Caroline Apovian, co-director of the Center for Weight Management and Wellness at Brigham and Women's Hospital in Boston said patients ask her about microdosing "all the time." "(But) there are no studies showing what it does," she cautioned in a TODAY segment that aired on Nov

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The common side effects of retatrutide are: Nausea Vomiting Diarrhea Constipation Fatigue Abdominal discomfort Early satiety Injection site reactions Increased heart rate Serious side effects of the medication include the following: Allergic or hypersensitivity reaction Liver problems Severe gastrointestinal issues Major depressive disorder Suicidal ideal Changes in mood and behavior Pancreatitis Low blood sugar levels (hypoglycemia) Cardiac arrhythmias The drug is still not FDA-approved and contraindications have not yet been determined