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doi: 10.1016/j.bioactmat.2023.10.002

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By analyzing the impact of PTMs, such as phosphorylation, ubiquitination, and acetylation, as well as DNA methylation, histone modifications, and non-coding RNA interactions on NRF2 stability, activity, and expression, the study reveals the complex cellular protection network mediated by NRF2

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Future research needs to define dose ranges, combination strategies, and subgroups most likely to benefit

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