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Wlaschek M, Scharffetter-Kochanek K

Site rotation is not optional Injecting in the same spot repeatedly causes lipohypertrophy, a condition where the subcutaneous fat layer thickens and hardens at the injection site

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Blood sugar fluctuations can mimic anxiety symptoms, causing shakiness, irritability, and a racing heart

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Research suggests berberine may reduce fasting blood glucose by 10-15 mg/dL in some patients, while GLP-1 medications typically lower glucose more aggressively and also produce appetite suppression