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Five groups were used as controls: 2 groups were ovariectomized, treated with saline and sacrificed on the 15 th and 28 th day post-ovariectomy, 1 group was non-ovariectomized but treated with saline, and 2 non-ovariectomized groups were treated with NaBPC157 (10 g or 10 ng/kg b.w., i.p.) once daily for 28 days

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