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Phang JM, Liu W, Hancock CN, Fischer JW

In pancreatic cancer cells, glutamine supports the production of NADPH via a noncanonical metabolic pathway 29 , and the mitochondrial glutamine transporter is strongly associated with glutaminolysis-induced NADPH generation 16

Impairments of intestinal arginine and NO metabolisms trigger aging-associated intestinal barrier dysfunction and inflammaging

The greater the exposure to toxins, the faster the body uses up its supply glutathione

Therefore, the results support the hypothesis that gut microbiota influences depression and provide a promising area of research for an improved knowledge of the etiology of the disease and future therapies