Back to Journals Journal of Inflammation Research Volume 14 IGF-1 Facilitates Cartilage Reconstruction by Regulating PI3K/AKT, MAPK, and NF-kB Signaling in Rabbit Osteoarthritis Authors Hossain MA , Adithan A, Alam MJ, Kopalli SR, Kim B, Kang CW, Hwang KC, Kim JH Received 20 April 2021 Accepted for publication 12 July 2021 Published 24 July 2021 Volume 2021:14 Pages 35553568 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Ning Quan Mohammad Amjad Hossain, 1 Aravinthan Adithan, 1 Md Jahangir Alam, 1 Spandana Rajendra Kopalli, 2 Bumseok Kim, 1 Chang-Won Kang, 1 Ki-Chul Hwang, 3 Jong-Hoon Kim 1 1 College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University, Iksan-city, Jeollabuk-Do, Republic of Korea
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and (2) as a negative acute-phase protein, its synthesis is inhibited by cytokines like IL-6 during a systemic inflammatory response, so low albumin levels also signify a more severe inflammatory state (70, 71)
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