--- Step 3: The Dosing Simple, Standard Boluses Two-step, easy-to-remember dosing: First Dose (Loading): 300 mg IV/IO bolus Give after the 3rd shock Second Dose (Repeat): 150 mg IV/IO bolus Give if rhythm persists, after the 5th shock --- Step 4: Post-Resuscitation The Infusion If ROSC is achieved but ventricular arrhythmias persist or recur: Maintenance Infusion: 1 mg/min for 6 hours then 0.5 mg/min for the next 18 hours (total 24-hour infusion period) --- Safety Check Monitor closely for: Hypotension ( blood pressure) Bradycardia (slow heart rate) If the patient has a pulse, administer the bolus slowly over 10 minutes to minimize these side effects
Here is what the evidence and community experience show at each stage
After removing 4487 duplicates, 7288 records underwent initial screening
The dosing principles are similar for both blends, though the slightly different compositions mean exact component doses vary
Subsequently, 60 studies were excluded due to the absence of alcohol-related outcomes, lack of GLP-1RA exposure, or unsuitable study design
The surface often contains visible scale and is usually rough on palpation