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ADA, a fully human recombinant IgG1 mAb, binds to both soluble and membrane-bound TNF- to induce cell-mediated cytotoxicity, complement activation, and T cell apoptosis, improving UC [184]
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Soluble UA/MSU-NLRP3-(IL-1) The researchers also concluded that MSU crystals could boost inflammation by their capacity to initiate and accelerate the assembly of NLRP3 inflammasome (60)
Clin Psychopharmacol Neurosci
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