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it has been used topically for decades without serious adverse events, and injectable formulations in animal models show no organ toxicity at doses up to 50 mg/kg" [8]

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Among other antioxidant enzymes and substances (Table 3), one study involving an important number of early PD patients showed the relationship between the presence of relatively higher levels of urate and the slower rates of clinical decline (Ascherio et al., Inflammatory and immunological markers CSF interleukin (IL) 1- levels were found to be normal in one study (Pirttila et al., 1994) and increased in three (Blum-Degen et al., 1996a