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Endurance training activates key regulators such as PGC-1, NRF1 and TFAM, leading to the production of new, functional mitochondria

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The apoE / mice fed with dietary TMAO for 8 weeks were found to have increased atheromatous plaques in the aorta and elevated serum lipids compared to the control group, which was demonstrated to be due to the inhibition of hepatic bile acid synthesis in mice possibly by downregulating Cyp7a1 (i.e., cholesterol 7-hydroxylase, the key regulatory enzyme of hepatic bile acid biosynthesis) (Ding et al., 2018)