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Beyond these functions, glutathione also aids in the regulation of cell proliferation and apoptosis, which are critical processes for tissue repair and regeneration

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In addition, CB-839 has been extensively studied in hematological malignancies such as acute myeloid leukemia (AML) (Gregory et al., 2019), myelodysplastic syndrome (MDS) (Okabe et al., 2022), and multiple myeloma (MM) (Das et al., 2014)

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Evidence for cysteine residues as major sites of arylation in vitro

The final biological evaluation confirmed that compound 62 (Figure 7) possessed the highest enzyme inhibitory activity, with an IC 50 of 2.5 nM