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The update should identify the effective date, the exact substance forms covered, any implementation conditions, and whether the agency announces an interim policy

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Journal of Research in Medical Sciences, 21, 45

If were not just talking about age-related changes - perhaps youve lost weight and thats caused your cheeks to prematurely deflate, or you want to tweak your natural cheeks and change their contour - in that case, fillers can be used as early as age 16 (though usually in minors theyre reserved for reconstructive work)