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A prospective study of 40 women with PCOS in Endocrine Practice (2021) found that 6 months of spironolactone at 100 mg/day improved self-reported sleep quality scores by 22% compared with baseline, though the study was small and uncontrolled
Barcelona, Spain: FEBSF, 1996 Di Marzio L, Moretti S, DAlo S, et al
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Unlike GLP-1 agonists that primarily act on the hypothalamus, amylin agonists exert their strongest effects through brainstem area postrema activation and dramatic gastric slowing exceeding that of any other peptide class
But digestive side effects like diarrhea and vomiting can cause additional losses through the GI tract
4C and Fig
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