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Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

As discussed in more detail in this section, we stated in the CY 2026 OPPS/ASC proposed rule that we were interested in additional evidence that demonstrates substantial clinical improvement with the use of the VersaVue TM Single-Use Flexible Cystoscope over other available treatment options (both single-use, disposable cystoscopes and reusable, reprocessed cystoscopes)

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Approximately 85 percent of patients report that side effects are mild, temporary, and manageable with support

The brains restricted antioxidant capacity, high energy demand, high levels of transition metals, such as iron and copper, and a high concentration of polyunsaturated fatty acids which can be subjected to lipid peroxidation [103,104,105] make the nervous system particularly vulnerable to oxidative stress [106]

PlexusDx supports both populations with flexible dosing and pricing structures