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Description

( Peptide InnOvatioN for the Early diabetEs tReatment (PIONEER) trial showed that GLP-1RAs caused an overall nausea rate of 15-20% and were associated with gastrointestinal adverse events, but these were temporary and dose-dependent ( Underlying mechanism The mechanisms that contribute to the beneficial effects of SGLT2i and GLP-1RAs in patients with T2DM have been extensively studied

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Keywords: Glucagon-Like Peptide-1 Receptor Agonists, Headache Disorders, Obesity, Migraine Disorders INTRODUCTION Obesity is a condition associated with significant personal and social burden

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